DERIVES 8-[6-[3-(AMINO)PROPOXY]-3-PYRIDYL]-1-ISOPROPYL-IMIDAZO[4,5-C]QUINOLEIN-2-ONE UTILISES EN TANT QUE MODULATEURS SELECTIFS DE L'ATAXIE TELANGIECTASIE MUTEE (ATM) KINASE POURLE TRAITEMENT DU CANCER
PIKE, KURT GORDON,BARLAAM, BERNARD CHRISTOPHE,HUNT, THOMAS ANTHONY,EATHERTON, ANDREW JOHN
申请号：
CA2997399
公开号：
CA2997399A1
申请日:
2016.09.15
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The specification generally relates to compounds of Formula (I): andpharmaceutically acceptable salts thereof, whereR1, R2, R3, R4 and R5 have any of the meanings defined herein. Thespecification also discloses the use of compounds of Formula (I)and salts thereof to treat or prevent ATM mediated disease, including cancer.The specification further relates to pharmaceuticalcompositions comprising substituted imidazo[4,5-c]quinolin-2-one compounds andpharmaceutically acceptable salts thereof； kitscomprising such compounds and salts； methods of manufacture of such compoundsand salts； and intermediates useful in suchmanufacture.
