Disclosed are methods for treating a cancer in a subject (e.g., a human) in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of formula I: or a pharmaceutically acceptable salt thereof, in combination with a vinca-alkaloid, or a pharmaceutically acceptable salt thereof. The subject may be very high risk or high risk for the cancer and may not respond to either agent administered as a sole therapy. The subject who has the cancer may also be refractory to at least one chemotherapy treatment, or is in relapse after treatment with chemotherapy, or both. The cancer may be a hematologic malignancy, such as leukemia or lymphoma, or a solid tumor cancer, such as pancreatic, lung and colon cancer.揭示用於治療需要治療癌症之個體(例如人)中的癌症之方法，其包含投予該個體治療上有效量之式I化合物：或其醫藥上可接受之鹽類與長春花生物鹼(vinca-alkaloid)或其醫藥上可接受之鹽類之組合。該個體可能處於癌症之極高風險或高風險中且可能不會對以單一療法形式投予之任一藥劑反應。罹患癌症之個體亦可能對至少一種化療治療反應不佳(refractory)，或處於進行化療治療之後的復發期，或為此二種情況。該癌症可為血液惡性腫瘤，諸如白血病或淋巴瘤，或實體腫瘤癌症，諸如胰臟癌、肺癌和結腸癌。
