The Board of Trustees of the Leland Stanford Junior University
发明人:
Justin KENKEL,Matthew ZHOU,Shelley Erin ACKERMAN,Edgar George ENGLEMAN,Michael Nathaniel ALONSO,Carolyn R. BERTOZZI
申请号：
US16626845
公开号：
US20200140556A1
申请日:
2018.06.27
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided are methods and compositions for treating an individual with cancer or infectious disease. Multivalent Dectin-2 stimulating agents are provided that include: (a) an agent that binds to Dectin-2 and stimulates Dectin-2 signaling； and (b) an antibody and/or an immunomodulatory agent, wherein (a) and (b) are conjugated to one another. In some cases, (a) is a mannobiose glycopolypeptide that binds to Dectin-2. In some cases (b) is a stimulatory ligand for a TLR (e.g., TLR7, TLR8, TLR7/8, TLR2, and the like). Methods of treating an individual with cancer and/or an infectious disease can include administering to the individual an effective amount of a Dectin-2 stimulating composition. In some cases, the Dectin-2 stimulating composition comprises a Dectin-2 stimulating glycopolymer. In some cases the Dectin-2 stimulating composition comprises a multivalent Dectin-2 stimulating agent.
