WILLIAM JAMES JONATHAN FINLAY,ORLA MARGARET CUNNINGHAM,YING SUN,HEATHER HONGRONG SHIH,QINGCONG LIN,LAIRD BLOOM
申请号：
ARP150102797
公开号：
AR101735A1
申请日:
2015.09.01
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
Claim 1: an isolated anti BDNF Antibody or an Antigen binding portion thereof, wherein: (a) The Antibody binds to human BDNF, and (b) Competes for Binding to Human and / or BDNF, BDNF binds to the same epitope in human,An Antibody Reference includes: (i) a variable region of heavy chain is the amino acid sequence of sec id no. 14 and a variable region of light chain is the amino acid sequence of sec id no. 16； or (ii) a variable region of heavy chain. Where the amino acid sequence of sec id no. 4 and a variable region of light chain comprising the seqMigration of amino acid SEC ID no. 6； or (iii) a variable region of heavy chain is the amino acid sequence of sec id no. 18 and a variable region of light chain is the amino acid sequence of sec id no. 20； or (iv) a variable region of heavy chain that includes And the amino acid sequence of sec id no. 22 and a variable region of light chain that includes the sequenceAmino Acid of sec id no. 24.Claim 24: a Nucleic Acid Molecule isolated in accordance with claim 23, wherein: (i) encodes a region that includes the sequence of heavy chain variable region of heavy chain SEC ID no. 4 and / or a region which includes the region of light chain The variable light chain SEC ID no. 6Or (ii) a region that includes the sequence of heavy chain variable region of heavy chain of sec id no. 14 and / or a region that includes the sequence of light chain variable region of light chain SEC ID no. 16Or (iii) a region that includes the sequence of heavy chain variable region of heavy chain of sec id no. 18 and / or a region that includes the sequence of light chain variable region of light chain SEC ID no. 20Or (iv) a region that includes the sequence of heavy chain variable region of heavy chain of sec id no. 22 and / or a region that includes the sequence of light chain variable region of light chain SEC ID no. 24.Claim 28: a method of producing an anti BDNF Antibody, characterized in that it comprises cultivating the host Cell accord
