KAMENECKA, THEODORE MARK,JIANG, RONG,SONG, XINYI,LOGRASSO, PHILIP,CAMERON, MICHAEL DARIN,DUCKETT, DEREK R.
申请号：
ES08829943
公开号：
ES2535166T3
申请日:
2008.09.03
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound or pharmaceutically acceptable salt thereof of formula Ib: ** Formula ** where: Z1 and Z2 are each CH； R1 is a 4-10 membered heterocyclic ring having 1 to 4 heteroatomic ring members selected from O, S (O) q, and N, where the heterocyclic ring is substituted with 0-2 R5； R2, when present, is independently Cl, F, Br, I, CF3, OCF3, C1-4alkyl, C2-4alkenyl, C2-4-alkynyl, NO2, -CN, ORa, N (Ra) 2, CORa , CO2Ra； R3 is H, CH3, CH2CH3, cyano, Cl, F, Br, or I； R4 is a phenyl ring substituted with 1-2 R4a groups； Each R4a is independently>； = O, Cl, F, Br, I, CF3, OCF3, C1-6alkyl substituted with 0-3 R5, C2-6alkenyl substituted with 0-3 R5, C2-6alkyl substituted with 0-3 R5, (CH2) pNO2, (CH2) pCN, (CH2) pOR, (CH2) pN (R) 2, (CH2) pCOR, (CH2) pOCOR, (CH2) pCO2R, (CH2) pCON (R) 2, (CH2) pOCON (R) 2, (CH2) pNRCOR, (CH2) pNRCO2R, (CH2) pNRCON (R) 2, (CH2) pC (>； = NH) NH2, (CH2) pSO2R, (CH2) pSO2N (R ) 2, (CH2) pNRSO2R, (CH2) pNRSO2N (R) 2, CH (CF3) NH2, or (CH2) p- (5-6 membered heterocyclic ring having between 1 and 4 heteroatomic ring members selected from O , S (O) q, and N), where the heterocyclic ring is substituted with 0-3 R5a, where a first group R4a is a 5-6 membered heteroaromatic ring； each R is independently H, C1-6alkyl substituted with 0-2 R5, C2-6alkenyl substituted with 0-2 R5, C2-6alkynyl substituted with 0-2 R5, 3-10 membered carbocyclic ring substituted with 0-2 R5, or 5-10 membered heterocyclic ring having between 1 and 4 heteroatomic ring members selected from O, S (O) q, and N, where the heterocyclic ring is substituted with 0-2 R5； or two Rs attached to the same N atom are taken together with the nitrogen atom to which they are attached to form a 5-8 membered heterocycloalkyl substituted with 0-2 R5； Each R5 is independently>； = O, Cl, F, Br, I, CF3, OCF3, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, NO2, -CN, ORa, N (Ra) 2, CORa, CO2Ra , WITH (Ra) 2, NRaCORa, NRaCO2Ra, NRaCON (Ra) 2, C (>； = NH) NH2, SO2Ra, SO2N (Ra) 2, NRaSO2Ra, NRaSO2N (Ra) 2,
