An oral hygiene device, which is embodied as a toothpick with floss, includes a toothpick body and a floss. The toothpick body has a closed end, an opening end, and a floss cavity formed between the closed end and the opening end, wherein the closed end of the toothpick body forms a tapering end. The floss, having a first end and an opposed second end, is received in the floss cavity of the toothpick body in a hidden manner. The toothpick body is used as a conventional toothpick to effectively remove detritus and plaques from the teeth and is easy to carry. The floss is normally protected within the toothpick body in a hidden manner to keep the floss in a hygiene purpose and is adapted for being pulled out of the floss cavity for flossing.