Akopian, Violetta,Akopian, Violetta,Minomi, Kenjiro,Minomi, Kenjiro,Niitsu, Yoshiro,Niitsu, Yoshiro,Payne, Joseph E.,Payne, Joseph E.,Knopov, Victor,Knopov, Victor,Witte, Richard P.,Witte, Richard P.
申请号：
HRP20181440
公开号：
HRP20181440T8
申请日:
2018.09.07
申请国别(地区):
HR
年份:
2018
代理人:
摘要：
What is described are pharmaceutical compositions comprising a double-stranded nuclei acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPTNH1-45a (SEQ ID NOS: 98 and 165), and SERPTNH1_51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 expression, including fibrosis.
