LE HIR Jerome,LE HIR Jerome,LOUBIERE Pascal,LOUBIERE Pascal,BARBIRATO Fabien,BARBIRATO Fabien,LINDLEY Nicholas,LINDLEY Nicholas
申请号：
SI201331114
公开号：
SI2885397T1
申请日:
2013.07.02
申请国别(地区):
SI
年份:
2018
代理人:
摘要：
The invention concerns a method for producing, on an industrial scale, capsular polysaccharide of Haemophilus influenzae type b (PRP) intended for vaccine purposes, according to which a strain of Haemophilus influenzae type b (Hib) is cultured in a culture medium, the culture supernatant is harvested and treated in order to extract the capsular polysaccharide therefrom, said culture medium comprising at least: —one source of carbon, —protoporphyrin, —salts, —amino acids, —NAD or NADH, —vitamins, —means for regulating the pH, characterised in that said culture medium is chemically defined.
