ANDERSON, Annaliesa Sybil,ARUMUGHAM, Rasappa Gounder,FARLEY, John Erwin,FLETCHER, Leah Diane,HARRIS, Shannon,JANSEN, Kathrin Ute,JONES, Thomas Richard,KHANDKE, Lakshmi,LOUN, Bounthon,PEREZ, John Lance
申请号：
HK16111644.9
公开号：
HK1223296A
申请日:
2016.10.07
申请国别(地区):
HK
年份:
2017
代理人:
摘要：
In one aspect, the invention relates to a composition including a first polypeptide having the sequence set forth in SEQ ID NO: 1 and a second polypeptide having the sequence set forth in SEQ ID NO: 2. In one embodiment, the composition includes about 120 μg/ml of a first polypeptide including the amino acid sequence set forth in SEQ ID NO: 1, 120 μg/ml of a second polypeptide including the amino acid sequence set forth in SEQ ID NO: 2, about 2.8 molar ratio polysorbate-80 to the first polypeptide, about 2.8 molar ratio polysorbate-80 to the second polypeptide, about 0.5 mg/ml aluminum, about 10 mM histidine, and about 150 mM sodium chloride. In one embodiment, a dose of the composition is about 0.5 ml in total volume. In one embodiment, two-doses of the composition induce a bactericidal titer against diverse heterologous subfamily A and subfamily B strains in a human.
