PROBLEM TO BE SOLVED: To provide a photoaged model human skin and model animal each useful for evaluating effect of cosmetics to preventing and improving photoageing, etc., and to provide a method for preparing those.SOLUTION: The method for preparing the photoaged human skin comprises continuously irradiating ultraviolet light having 80-100 mJ/cm2 B wavelength for 4-8 weeks to a transplanted skin of immunodeficient nonhuman animal to which human skin is transplanted and allow the irradiated skin to stand at least for three weeks after irradiation. The human photoageing model skin and the model animal are each prepared by the method.COPYRIGHT: (C)2007,JPO&INPIT【課題】 化粧料等の光老化予防及び改善効果を評価するために有用なヒト光老化モデル皮膚、モデル動物及びそれらの作成方法の提供。【解決手段】 ヒト皮膚を移植した免疫不全非ヒト動物の当該移植皮膚に、80~100mJ/cm2のB波長紫外線を4~8週間連続照射し、照射後少なくとも3週間放置することを特徴とするヒト光老化皮膚モデルの作成方法、当該方法により作成されたヒト光老化モデル皮膚、モデル動物。【選択図】なし
