The present invention relates to isolated liver progenitor stem cells, andcell population thereof, wherein said progenitor stem cells originate fromadult liver, esp. of human. The present invention also relates to the use ofsaid isolated progenitor stem cells in medicine, hepatology, inborn errors ofliver metabolism, transplantation, infectious diseases, liver failure. Thepresent invention also relates to methods of isolating these cells, theirculture, characterization before and after differentiation, and their use fortransplantation, animal models of human disease, toxicology and pharmacology.
