COPOLYMÈRE EN BLOCS POUR ADMINISTRATION INTRAPÉRITONÉALE CONTENANT UN AGENT ANTICANCÉREUX, PRÉPARATION DE MICELLE, ET AGENT DE TRAITEMENT DU CANCER COMPRENANT LA PRÉPARATION DE MICELLE EN TANT QU'INGRÉDIENT ACTIF
To provide a therapeutic method using a water soluble, high molecular weight block polymer to enable that an intraperitoneally administered anti-cancer agent may maintain for a long-term retention in the abdominal cavity to enoughly exert the effect of the anti-cancer agent and reduce adverse side-effects thereof. A therapeutic agent as a micelle preparation, comprising a copolymer having a hydrophilic polymeric moiety and a polycarboxylic acid derivative moiety； and an anti-cancer agent bonding to or encapsulated in the copolymer, wherein the micelle preparation may exhibit sustained drug release capability, and enables an extension of a retention time period of the anti-cancer agent in an abdominal cavity, is provided. A superior life-prolonging effect was found in an Intraperitoneal administration mouse model compared with a case in which only an encapsulated drug is administered, and thus the present invention was completed accordingly.
