Discloses a vaccine comprising an injectable oil-in-water emulsion comprising: On immunogen (peptide, antigen) A saponin (QS21, QS-21, QS 21) in the amount about 0.7 mg/dose to about 1.3 mg/dose Aluminium hydroxide in the amount of about 0.065% to 0.42% A mineral oil A non-ionic hydrophilic surfactant with a high hydrophilic-lipophilic balance (HLB) value between 13 -40, selected from ethoxylated fatty acid monoesters of sorbitan and ethoxylated fatty acids； and A non-ionic hydrophilic surfactant with a low hydrophilic-lipophilic balance (HLB) value between 9 and 13 selected from ethoxylated fatty acid triesters/diesters/monoesters of sorbitan, ethoxylated castor oil and ethoxylated fatty acids.
