Yoshiro Niitsu,Victor Knopov,Joseph E. Payne,Zheng Hou,John A. Gaudette,Violetta Akopian,Richard P. Witte,Mohammad Ahmadian,Loren A. Perelman,Yasunobu Tanaka,Priya Karmali,Sridhar C. Nagarajan
申请号：
US14256306
公开号：
US09242001B2
申请日:
2014.04.18
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Here described are compounds of formula I:wherein R1 and R2 is independently selected from a group consisting of C10 to C18 alkyl, C12 to C18 alkenyl, and oleyl group； wherein R3 and R4 are independently selected from a group consisting of C1 to C6 alkyl, and C2 to C6 alkanol； wherein X is selected from a group consisting of —CH2—, —S—, and —O— or absent； wherein Y is selected from —(CH2)n, —S(CH2)n, —O(CH2)n—, thiophene, —SO2(CH2)n—, and ester, wherein n=1-4； wherein a=1-4； wherein b=1-4； wherein c=1-4； and wherein Z is a counterion； as well as compositions and pharmaceutical formulations including compounds of formula I which are useful for the delivery of therapeutic agents； and methods of using these compositions and formulations.
