您的位置: 首页 > 农业专利 > 详情页

STAT3 INHIBITOR WITH ANTICANCER ACTIVITY AND ASSOCIATED PROCEDURES
专利权人:
UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.;YALE UNIVERSITY;UNIVERSITY OF SOUTH FLORIDA
发明人:
JOVE, RICHARD,SEBTI, SAID M.,TURKSON, JAMES,HAMILTON, ANDREW D.
申请号:
DK07868993
公开号:
DK2120958T3
申请日:
2007.12.05
申请国别(地区):
DK
年份:
2013
代理人:
摘要:
A small-molecule Stat3 dimerization inhibitor, S3I-M2001, is described and the dynamics of intracellular processing of activated Stat3 within the context of the biochemical and biological effects of the Stat3 chemical probe inhibitor are elucidated. S3I-M2001 is a newly-identified oxazole-based peptidomimetic of the Stat3 Src Homology (SH) 2 domain-binding phosphotyrosine peptide that selectively disrupts active Stat3:Stat3 dimers. Stat3-dependent malignant transformation, survival, and migration and invasion of mouse and human cancer cells harboring persistently-activated Stat3 were inhibited by S3I-M2001. S3I-M2001 inhibited Stat3-dependent transcriptional regulation of tumor survival genes, such as Bcl-xL. The disclosed compound is useful as a new potential treatment for certain cancers.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充