MODIFICEREDE OLIGONUKLEOTIDER TIL INHIBERING AF TELOMERASE

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专利权人:

GERON CORPORATION

发明人:

GRYAZNOV, Sergei,PONGRACZ, Krisztina

申请号：

DK04783801

公开号：

DK1667522T3

申请日:

2004.09.09

申请国别(地区):

DK

年份:

2018

代理人:

摘要：

Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with a high potency and have superior cellular uptake characteristics.

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