UNIVERSITE DE MONTPELLIER;AxLR SATT DU LANGUEDOC ROUSSILLON (SATT AXLR);INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
发明人:
申请号：
EP16305669.0
公开号：
EP3254698A1
申请日:
2016.06.08
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
The present invention relates to FLT3 receptor inhibitor for use in the treatment of neuropathic pain and chronic pain comprising a neuropathic component, wherein the daily dosage range per human adult per day of said FLT3 receptor inhibitor consists of a dosage range determined by a method comprising the steps of:- (i) determining the minimal inhibiting dose of said FLT3 receptor inhibitor that induces the maximal inhibition of mechanical pain hypersensitivity,- (ii) converting said dose to the Human Equivalent Dose (HED) by the allometric correction method, , and- (iii) establishing a daily dosage range per human adult per day wherein(iii-1) the lower limit of the said daily dosage range per human adult per day is the greater value between HED/20 determined via a rat model and 0.001 mg, and(iii-2) the upper limit of the said daily dosage range is the lower value between HED*20 determined via a rat model and 50 mg.
