Microcellular polyhipe polymer scaffold suitable for growth of living matter for biomedical applications, obtainable by polymerising a high internal phase emulsion, comprising a homogeneous cross-linked open cellular material defined by a bulk polymer matrix having a surface and an interface with an internal phase, and having porosity greater than 75 % comprising emulsion derived pores of diameter in the range of 0.1 to 10,000 micron and emulsion derive pore interconnects of diameter in the range of up to 100 micron, wherein the scaffold comprises a plurality of discrete and/or interpenetrating zones: at the polymer surface within its bulk matrix at the interface between polymer and internal phase and/or between adjacent but distinct pores and/or interconnects, characterised by form and dimension of pore and interconnect type within each zone, and location of zones wherein adjacent or interpenetrating zones are distinguished by boundaries which may be between or contained within adjacent pores and/or interconnects in respective zones, whereby zones are suitable for regulating positioning and/or morphology of living matter a biologically active system, or organ support module comprising the scaffold and methods and processes for preparation thereof and use thereof.La présente invention concerne une structure de polymère microcellulaire obtenue par polymérisation démulsion à phase interne élevée (HIPE), permettant la culture de matière vivante destinée aux applications médicales. Cette structure est constituée dun matériau cellulaire homogène ouvert et réticulé, défini par une matrice polymérique condensée présentant une surface interne et une interface avec une phase interne, de porosité supérieure à 75 %, constituée de pores, dus à lémulsion, de diamètres compris entre 0,1 et 10000 microns et dinterconnexions de pores de diamètre denviron 100 microns. Ladite structure comprend une pluralité de zones discrètes et/ou interpénétrantes: à la surface du polymère à lintér
