Provided herein are methods of treating, preventing, and managing metabolic or cardiovascular disorders and methods of reducing cardiovascular risk with FGF21 protein variants, including Fc-FGF21 variant fusion proteins.本文提供了治療、預防和管理代謝或心血管障礙之方法,以及用包括Fc-FGF21變體融合蛋白在內的FGF21蛋白變體降低心血管風險之方法。