Provided herein is a CD40L-Fc fusion protein and methods of using the fusion protein in the treatment of cancer comprising administering the CD40L-Fc fusion protein or the CD40L-Fc fusion protein in combination with one or more immune checkpoint inhibitors (e.g., an anti-CTLA4 antibody, anti-PD-L1 antibody).本文中提供CD40L-Fc融合蛋白及使用該融合蛋白治療癌症之方法,該方法包含投與該CD40L-Fc融合蛋白或該CD40L-Fc融合蛋白與一或多種免疫檢查點抑制劑(例如,抗CTLA4抗體、抗PD-L1抗體)之組合。