The invention provides nine oligonuleotides with sequences of SEQ ID NO: 1-9or their functional homologues or a composition comprising the same and amethod for treating B cell neoplasm by using the oligonuleotides or theirfunctional homologues or the composition comprising the oligonuleotides. Theoligonuleotides induce the apoptosis of B cell neoplastic cells, up-regulateCD40 on B cell neoplastic cells and stimulate the production of IL-10 from Bcell neoplastic cells.