U.S. GOVERMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFIRS
发明人:
M. Peter Marinkovich,Carl Gustaf Maarten Winge
申请号：
US16302325
公开号：
US20190289834A1
申请日:
2017.05.19
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A biologically relevant animal model for psoriasis is provided. Epidermal-immune interactions governing epidermal tissue homeostasis are altered in psoriasis, an inflammatory disease affecting one in thirty adults. Here, we characterize Rac1 as a key mediator of this process. Rac1 activation was consistently elevated in psoriatic epidermis and primary psoriatic human keratinocytes (PHKC).
