GENEXINE, INC.;POSTECH ACADEMY-INDUSTRY FOUNDATION
发明人:
Young Chul SUNG,Ji Yeung LEE,Mi-Young SONG,Hye Seong LIM,Byung Ha LEE
申请号：
US15313220
公开号：
US20170189476A1
申请日:
2015.05.26
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to a fusion protein composed of the extracellular domain of PD-L1 and a modified immunoglobulin Fc region. The extracellular domain of PD-L1 and a fragment thereof have excellent immunomodulatory activity, and can be used as an immunomodulatory agent if a modified immunoglobulin Fc region is coupled thereto. Accordingly, the PD-L1 fusion protein according to the present invention demonstrated its excellent effect in disease models of inflammatory bowel disease, colitis, psoriasis, asthma and arthritis, and thus can be very effectively used for the treatment of such diseases.
