Multiple doses of topical ophthalmic composition containing a - 1 - 1H indole carboxamide and use it for the treatment of Eye Disease.More specifically, This refers to an ophthalmic aqueous Composition of multiple dose (e.g., Solution, suspension, emulsion or similar) that contains a 1h indole - 3 - carboxamide (e.g.N - (1 - methyl - 5 - (trifluoromethyl) - 1H pyrazole - 3 - yl) - 5 - ((4 - (methylamino) methyl) pyrimidin-4-yl) oxy) - 1H indole - 3 - carboxamide) and use it for the treatment of ocular disease in the posterior part of the eye, such as age-related macular degeneration (AMD).Claim 1: a multiple dose aqueous ophthalmic composition comprising: an effective concentration of a - 1 - 1H indole carboxamide adequate to treat a condition at the back of the eye, where the - 1 - 1H indole carboxamide is a compound of the formula (1) or a Salt farmac u00e9u This politically acceptable.Where: r u00b9 is Hydrogen or alkyl c u2081 u208b u2086； r u00b3 is Hydrogen or alkyl c u2081 u208b u2086； r u2075 is Hydrogen or Halogen； r u2077 is c u2081 u208b u2086 Hydrogen or alkyl； X is o or s； r u2078 is selected from the group consisting of hydrogen and alkyl c u2081 u208b u2084； r u2079 is selected from the group consisting of (CR u00b9 u00b9r u00b9 u00b2) u2099nr u00b9 u00b3r u00b9 u2074 (cr u00b9 u00b9r u00b9 u00b2) u2099 - heterocycle (cr u00b9 u00b9r u00b9 u00b2) u2099or u00b9 u2075 (cr u00b9 u00b9r u00b9 u00b2 u2099c (,) and (OR) er u00b9 u00b3 cr u00b9 u00b9r u00b9 u00b2) u2099s (or u2098r u00b9 u2077 r u2078 and r u2079)； or,Taken together with the Atoms that are United to form a Heterocyclic Ring of 4 - 7 members that have 1 or 2 saturated Ring heteroatoms selected from N, o or s, the Heterocyclic ring is replaced by 0, 1 or 2 groups are selected independently of the Grup Or is c u2081 u208b u2086 haloalquilo c u2081 u208b u2086, alkyl, halogen, hidroxialquilo c u2081 u208b u2086, aminoalquilo c u2081 u208b u2086,Cicloalquil c u2083 u208b u2087 alkyl c u208
