The present invention [2 - ({4 - [(dimethylamino) imino] phenyl} carbonyl) -5-methoxyphenyl] a -N- (5- chloro (2-pyridyl)) carboxamide using the combination therapy which contains, to a method and pharmaceutical composition thereof for the treatment of thrombotic disease (s).Thrombotic disorders, blood coagulation, synergism본 발명은 [2-({4-[(디메틸아미노)이미노메틸]페닐}카보닐아미노)-5-메톡시페닐]-N-(5-클로로(2-피리딜))카복스아미드를 함유하는 병용 요법을 사용하여 혈전성 질환(들)을 치료하는 방법 및 이의 약제학적 조성물에 관한 것이다.