PROBLEM TO BE SOLVED: To provide a method for prolonging the effective time of skin antiaging treatment using Botulinum toxin.SOLUTION: The method comprises administering Botulinum toxin to an area to be treated, in combination with the administration of a cosmetic composition comprising: a cosmetically effective amount of at least one SNAP-25 protein-derived peptide and/or at least one enkephalin-derived peptide； and at least one cosmetically acceptable excipient or adjuvant.EFFECT: The cosmetic composition prolongs in time the antiaging effectiveness of Botulinum toxin administered in areas of facial and/or neck skin.SELECTED DRAWING: Figure 1【課題】ポツリヌス毒素を用いる皮膚の抗老化治療の効果時間を長引かせるための方法の提供。【解決手段】美容的に有効な量の少なくとも１つのＳＮＡＰ－２５タンパク質由来のペプチド及び／又は少なくとも１つのエンケファリン由来のペプチドと、少なくとも１つの美容的に許容可能な賦形剤又は補助剤とを含む美容組成物の投与と併用して、ポツリヌス毒素を治療領域に投与する、方法。【効果】前記美容組成物は、顔及び／又は首の皮膚の領域に投与されたボツリヌス毒素の抗老化効果の時間を長引かせる。【選択図】図１
