methods for increasing and decreasing an effector function of a parental polypeptide and a parent antibody, for enhancing an effector function of a combination of at least one first and a second parent polypeptide, for inducing an effector response against a cell, cell membrane, or virion, to increase the specificity of a combination of at least a first and a second parent polypeptide, variant of a parent polypeptide, composition, and part kit
ARAN FRANK LABRIJN,FRANK BEURSKENS,JANINE SCHUURMAN,PAUL PARREN,ROB N. DE JONG
申请号：
BR112014000264
公开号：
BR112014000264A2
申请日:
2012.07.06
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
Described herein are polypeptides and related antibodies comprising a variant Fc domain. The variant Fc domain provide for stabilized Fc:Fc interactions when the polypeptide(s), antibody or antibodies are bound to its target, antigen or antigens on the surface of a cell, thus providing for improved effector functions, such as CDC-response.
