FUNDACION INSTITUTO DE INVESTIGACION SANITARIA DE SANTIAGO DE COMPOSTELA (FIDIS);SERVIZO GALEGO DE SAUDE (SERGAS)
发明人:
DE LA FUENTE FREIRE, MARIA,LOPEZ LOPEZ, RAFAEL,LOPEZ BOUZO, BELEN,VAZQUEZ RIOS, ABI JUDIT,ALONSO NOCELO, MARTA
申请号：
CA3088223
公开号：
CA3088223A1
申请日:
2019.01.15
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
In the present invention, the development of various oil-in-water (O / W) nanoemulsions containing an oil phase or oil core, preferably selected from vitamin E or oleic acid, stabilized by a sphingolipid of the sphingomyelin type, and optionally other lipids such as phospholipids, cholesterol, octadecylamine, DOTAP (N- [1- (2,3-Dioleoyloxy) propyl] -N, N, N-trimethylammonium methyl-sulfate), and PEGylated derivatives (derivatives with polyethylene glycol), for use as a nanotech vehicle, in particular for the management of cancer and metastatic disease, is herein described. Said nanoemulsions can be functionalized with ligands capable of interacting or binding to receptors expressed on the cell membrane of tumor cells, and in particular capable of interacting or binding to receptors expressed on the membrane of primary and/or disseminated or metastatic tumor cells. Also, antitumor drugs or therapeutic biomolecules can be encapsulated in said nanoemulsions and, finally, contrast agents can be incorporated for their use in the in vivo diagnosis in said nanoemulsions.
