INC.;DUQUESNE UNIVERSITY OF THE HOLY SPIRIT;CABERTECH;CABERTECH, INC.
发明人:
MCGOWAN, KENNETH A.,GAWALT, ELLEN S.,PALCHESKO, RACHELLE
申请号：
CA2843144
公开号：
CA2843144A1
申请日:
2012.07.12
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
A functionalized composition and resulting functionalized body or prosthesis for in vitro and in vivo use comprising at least one calcium phosphate containing phase that is functionalized with a linker group comprising at least one of an organic acid molecule, a phosphoric acid, an amine, N,N-dicyclohexylcarbodiimide, and 3-maleimidopropionic acid N-hydroxysuccinimide ester, wherein the linker group provides for a reactive location for the attachment of one or more of a chemical and/or a biologically active moiety to the calcium phosphate containing phase. The functionalized compositions have a pliable physical property when mixed with water and adhere to natural bone and subsequently harden at ambient temperatures. Methods of manufacturing a functionalized artificial prosthesis that may be used as artificial bones, joints, in-vitro support structures, and in-vivo support structures for cells, tissues, organs, and nerve growth and regeneration are disclosed. Methods of repairing a bone, vertebrae, or tissue structures using the functionalized compositions are provided.
