UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人:
PARHAMI, FARHAD,STAPPENBECK, FRANK,JUNG, MICHAEL,PIERCE, WILLIAM M., JR.,MERTEN, KEVYN,TAYLOR, GRANT K.
申请号：
CA2911205
公开号：
CA2911205A1
申请日:
2014.05.02
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Compounds and compositions for the treatment of bone disorders are presented. Oxysterol compounds and compositions for the treatment of bone disorders are presented. The compounds are conjugates or derivatives of (3S,5S,6S,8R,9S,10R,13S,14S,17S)-17-[(2S)-2-hydroxyoctan-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17- tetradecahydro-1H-cyclopenta[a]phenanthrene-3,6-diol with a BTA-linker, such as from a tetracycline fragment, attached to 3-position, 6-position, or 20-position. These osteogenic oxysterol compounds stimulate hedgehog signaling pathway. The various linker units are susceptible to certain esterases.
