A compression splint is provided for reduction, compression and stabilization of spinal, pelvic, and long bone fractures. The compression splint includes a plurality of plates selectively disposed at a plurality of positions of a fracture site a plurality of inflatable cushions, each cushion positioned between respective plates of the plurality of plates and the fracture site and a support means for supporting the plurality of plates and plurality of cushions compressively against the fracture site in three dimensions, Additionally, the plates of the compression splint can be adjusted, removed or additional plates added to further customize the compressive force applied to the fracture site.