BLANDA WENDY M.,SPADA LON T.,ORILLA WERHNER C.,WHITCUP SCOTT M.,LIN JOAN-EN,RUIZ GUADALUPE,HUGHES PATRICK M.,ROBINSON MICHAEL R.,WELTY DEVIN F.
申请号：
NZ61929707
公开号：
NZ619297A
申请日:
2007.11.09
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed is a biocompatible, injectable intraocular drug delivery system comprising: (a) a plurality of microspheres with an average diameter between about 8 microns and about 14 microns, and (b) an aqueous vehicle for the microspheres, wherein the microspheres consist essentially of: (1) aa therapeutic agent which is a prostaglandin or bimatoprost, latanoprost or 7-{ 2-[5-(3-fluoro-4-methyl-thiophen-2-yl)-3-methoxy-pent-1-enyl]-3,5-dihydroxycyclopentyl} -hept-5-enoic acid ethyl amide, and (2) one or more biodegradable polymers, all of which biodegradable polymers are polylactic acid (PLA) polymers, and wherein the drug delivery system has a viscosity which permits the drug delivery system to be injected into an intraocular location through a 20 to 30 gauge syringe needle.
