Connor, Edward M.,Losonsky, Genevieve,DallAcqua, William,Young, James F.,Wu, Herren
申请号：
AU2012200987
公开号：
AU2012200987A1
申请日:
2012.02.20
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2012200987A120120308.pdf#####METHODS OF PREVENTING AND TREATING RSV INFECTIONS AND RELATED CONDITIONS Abstract The present invention provides methods for preventing, managing, treating and/or s ameliorating a Respiratory Syncytial Virus (RSV) infection (e.g., acute RSV disease, or a RSV upper respiratory tract infection (URI) and/or lower respiratory tract infection (LRI)), otitis media (preferably, stemming from, caused by or associated with a RSV infection, such as a RSV URI and/or LRI), and/or a symptom or respiratory condition relating thereto (e.g., asthma, wheezing, and/or reactive airway disease (RAD)) in a 10 subject, comprising administering to said human an effective amount of one or more antibodies that immunospecifically bind to one or more RSV antigens vith a high affinity and/or high avidity. In some embodiments, one or more antibodies comprise a modified IgG constant domain, or FcRn-binding fragment thereof resulting in longer in vivo serum half-life. In particular embodiments the methods of the invention comprising 15 administering to subject an effective amount of one or more modified antibodies that immunospecifically bind to one or more RSV antigens with an association rate (ko,) of at least 2 x 105 M~s~ and a dissociation rate (koff) of less than 5 x 10~4 S-1.
