The compounds included in the formula {1} include compounds that are inhibitors of the HIV Protease and other compounds that can be metabolized in vivo hiv protease inhibitors. The compounds and their pharmaceutically acceptable salts are useful in the prophylaxis or treatment of infection by HIV and for prophylaxis, treatment, or delay the onset of AIDS.The compounds and their salts can be used as ingredients in Pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or Vaccines.Claim 1: a compound of formula (1) or a pharmaceutically acceptable Salt thereof, which is ch u2082: u or V； y u00b9, y u00b2 y u2074 are selected independently, or E (R) between C and N； X is selected from H and nr u2077r u2078 independently； Z is selected from the group which was And in the compound formulas {2} - {14}； l is a Linking selected a link between (a), (b) - ch u2082 -(c) - C (o) - (d) -, - C (o) - ch u2082 * * or - C (o) - ch u2082 - * *, (e) - ch u2082 - ch u2082 - C (o) - * * or - C (o) - ch u2082 - ch u2082 - * * and (f) a remainder formula {15} or {16}, where * * shows the point of coupling to the morpholine and when z is a remainder formula {17} then l is not a Link； R is selected from h, Halo, Hydro C u2081 u208b u2084 XI, alkyl, alkoxy alkyl c u2081 u208b u2084, c u2081 u208b u2084 - S (o) u2096 - cf u2083, CN, Benzyl,Or Two R groups on adjacent Atoms can join together with those Atoms that are coupled to form a condensate phenyl pyridazine hydrochloride, pyridine, pyrazine, pyrimidine or triazine, each of them being optionally substituted with 1 to 4 substituents selected independently You among the group consisting of: c u2081 u208b u2084 c u2081 u208b u2084 Halo, alkyl, alkoxy,Cf u2083 and CN； each K is independently 0, 1 or 2, R and T are independent； each 1, 2, 3 or 4； za is selected from the group consisting of: (1) hydrogen, alkyl c u2081 u208b u2081 u2080 (2), (3) alquenilo c u2082 u208b u2081 u2080 cycloalkyl
