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NEW APPLICATIONS OF SODIUM 4-PHENYLBUTYRATE (4FB) AND ITS PHARMACEUTICAL ACCEPTABLE SALTS
专利权人:
ПРОЙЕКТО ДЕ БИОМЕДИСИНА СИМА; С.Л. (ES)
发明人:
ФРЕЧИЛЛА-МАНСО Диана-Сара (ES),ГАРСИЯ-ОСТА Ана-Мария (ES),ПЕРЕС-МЕДИАВИЛЬЯ Луис-Альберто (ES),РИКОБАРАСА-АБАРКЕРО Ана-Лоурдес (ES)
申请号:
RU2010138638/15
公开号:
RU2010138638A
申请日:
2009.03.06
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. 4-Phenylbutyrate (4FB) or a pharmaceutically acceptable salt thereof for use in the prevention and / or treatment of Alzheimer's disease. ! 2. The use of 4FB or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the prevention and / or treatment of Alzheimer's disease. ! 3. 4FB according to claim 1, wherein its pharmaceutically acceptable salt is 4FB sodium salt. ! 4. The use of 4FB according to claim 2, where its pharmaceutically acceptable salt is the 4FB sodium salt. ! 5. A pharmaceutical composition comprising 4FB sodium salt and a pharmaceutically acceptable carrier for use in the prevention and / or treatment of Alzheimer's disease. ! 6. A pharmaceutical combination, characterized in that it comprises 4 FB or any of its pharmaceutically acceptable salts as a first active ingredient, a second active ingredient that is an inducing or auxiliary agent for cleansing β-amyloid deposits in the brain, and a pharmaceutically acceptable carrier . ! 7. The combination according to claim 6, which includes 4FB sodium salt as the first ingredient. ! 8. The combination according to claim 6 or 7, wherein the agent inducing the purification of β-amyloid deposits in the brain is a metal chelating agent. ! 9. The combination of claim 8, in which the specified metal chelating agent is clioquinol. ! 10. The combination according to claim 6 or 7, in which the catabolizing enzyme is an agent that induces the purification of β-amyloid deposits in the brain. ! 11. The combination of claim 10, wherein said inducing agent is an insulin-destructive enzyme or neprilysin. ! 12. The combination according to claim 6 or 7, in which the agent inducing purification1. 4-Фенилбутират (4ФБ) или его фармацевтически приемлемая соль для применения с целью предупреждения и/или лечения болезни Альцгеймера. ! 2. Применение 4ФБ или его фармацевтически приемлемой соли для получения лекарственного средства, предназначенного для предупреждения и/или лечения болезни Альцге
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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