Use of low temperature and low pH in cell culture

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专利权人:

ワイス・エルエルシー

发明人:

ゴメス， ホセ マヌエル,ヒラー， グレゴリー ウォルター,ゴメス, ホセ マヌエル,ヒラー, グレゴリー ウォルター

申请号：

JP2010506424

公开号：

JP5557736B2

申请日:

2008.04.22

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

The present disclosure provides a method of reducing protein misfolding and aggregation in the cell culture by growing the cell culture at a reduced temperature and/or reduced pH. As a result, the quality of the protein produced in the cell culture is greatly improved. Thus, the present disclosure facilitates improvements in the efficacy of therapeutic proteins produced in cell culture.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/