Wouter de Graaff,Janneke Sophie Groen,Marcus Antonius Bernardus Kruft,Johannes Antonius Hendrikus Van Laarhoven,Herman Vromans,Raymond Zeeman
申请号：
US14312034
公开号：
US20140302115A1
申请日:
2014.06.23
申请国别(地区):
US
年份:
2014
代理人:
摘要：
A drug delivery system consisting of one or more compartments and comprising a progestogenic compound dissolved in a thermoplastic polyethylene vinylacetate copolymer whereby,if the delivery system consists of one compartment, the compartment comprises(i) a core of a thermoplastic polyethylene vinylacetate copolymer comprising the progestogenic compound, such progestogenic compound being dissolved in the polyethylene vinylacetate copolymer up to a concentration below the saturation level at 25° C., and an estrogenic compound； and(ii) a skin of a thermoplastic polyethylene vinylacetate copolymer covering the core, said skin being permeable for both compounds； if the delivery system consists of more than one compartment, only one compartment comprises(iii) the progestogenic compound, such progestogenic compound being dissolved in a core of a thermoplastic polyethylene vinylacetate copolymer up to a concentration below the saturation level at 25° C., and an estrogenic compound； and(iv) a skin of a thermoplastic polyethylene vinylacetate copolymer covering the core, said skin being permeable for both compounds.
