NOVEL METHODS FOR THE MEDICAL TREATMENT AND/OR INHIBITION OF THE DEVELOPMENT OF OSTEOPOROSIS, BREAST CANCER, HYPERCHOLESTEROLEMIA, HYPERLIPIDEMIA OR ATHEROSCLEROSIS IN SUSCEPTIBLE WARM-BLOODED ANIMALS INCLUDING HUMANS INVLOVING ADMINISTRATION OF SELECTIVE ESTROGEN RECEPTOR MODULATOR PARTICULARLY COMPOUNDS HAVING THE GENERAL STRUCTURE : AND AN AMOUNT OF A SEX STEROID PRECURSOR SELECTED FROM THE GROUP CONSISTING OF DEHYDROEPIANDROSTERONE, DEHYDROEPIANDROSTERONE SULFATE, ANDROST-5-ENE-3β, 17β-DIOL AND COMPOUNDS CONVERTED IN VIVO TO ONE OF THE FOREGOING PRECURSOR. FUTHER ADMINISTRATION OF BISPHOSPHONATES IN COMBINATION WITH SELECTIVE ESTROGEN RECEPTOR MODULATORS AND/OR SEX STEROID PRECURSOR IS DISCLOSED FOR THE MEDICAL TREATMENT AND/OR INHIBITION OF THE DEVELOPMENT OF OSTEOPOROSIS. PHARMACEUTICAL COMPOSITIONS FOR DELIVERY OF ACTIVE INGREDIENT(S) AND KIT(S) USEFUL TO THE INVENTION ARE ALSO DISCLOSED.
