A liquid and gas separator system includes an inlet (34) that receives a first gas sample. The first gas sample at least partially includes liquid introduced from a patient in a gaseous or liquid form. The liquid and gas separator system also includes a first chamber (40) coupled to the inlet (34) and configured to receive the first gas sample. The first chamber (40) includes a drain aperture (42). An outlet (36) is coupled to the first chamber (40) and is configured to receive a second gas sample from the first chamber (40). The second gas sample is derived from the first gas sample and that is the second gas sample includes less liquid than the first gas sample. The second chamber (50) is substantially sealed around the first chamber (40). The first chamber (40) receives a combined gas and liquid from the inlet and separates at least some of the liquid from the gas. The first chamber (40) is configured to have liquid deposited at the bottom of the first chamber (40). The liquid deposited at the bottom of the first chamber (40) is subsequently transferred to the second chamber (50) through the drain aperture (42) by a pumping action created by a pressure gradient in the inlet line (16). The pressure gradient is created by liquid water at least partially blocking the free flow of gas through the sample line inlet (16).