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METHOD FOR MANUFACTURING DIASTEREOMER OF CITRIC ACID DERIVATIVE
专利权人:
OTSUKA PHARMACEUTICAL FACTORY, INC.;ADABIO CO., LTD.
发明人:
Katsuya HIRAISHI,Hiroyuki SOMA,Fumie JIMMA,Taro ADACHI,Ippei YAMAOKA,Naoyuki ENDO
申请号:
US16606376
公开号:
US20200055821A1
申请日:
2018.04.23
申请国别(地区):
US
年份:
2020
代理人:
摘要:
By using ion exchange column chromatography or calcium carbonate to an aqueous solution containing a compound A represented by the following formula and citric acid, citric acid in the aqueous solution is removed and a crystalline compound A is obtained by being thereafter subjected to several steps. Further a high-purity noncrystalline compound A is obtained by using calcium carbonate, sulfuric acid, an organic solvent and the like to the aqueous solution containing the compound A and citric acid to remove citric acid and the crystalline compound A in the solution. The configuration of the crystalline compound A is an SS isomer in the RS notation system. The configuration of the noncrystalline compound A is an SR isomer.
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