HECHT, SIDNEY M., UNIVERSITY OF VIRGINIA,MILLER, GUY M., EDISON PHARMACEUTICALS, INC.
申请号：
DK06784530
公开号：
DK1888059T3
申请日:
2006.06.01
申请国别(地区):
DK
年份:
2015
代理人:
摘要：
Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), or Kearns-Sayre Syndrome (KSS) are disclosed, as well as compounds useful in the methods of the invention, such as alpha-tocopherol quinone. Methods and compounds useful in treating other disorders are also disclosed. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed.
