The present invention provides a pharmaceutical composition for reducing local fat. The pharmaceutical composition for reducing local fat comprises drug-containing micelles made of surfactants, and curcumin encapsulated in said drug-containing micelles. This pharmaceutical composition for reducing local fat can reduce the fat at the administration site, and has the advantages of high stability, high fat tissue bioavailability, few side effects, and sustained release.本發明提供一種用於減少局部脂肪的醫藥組成物,包含界面活性劑所形成的複數個含藥微胞、以及被包覆在所述含藥微胞中的薑黃素。所述用於減少局部脂肪的醫藥組成物可減少施用部位的脂肪,且具有高安定性、高度脂肪組織生體可用率、低副作用、以及緩釋等優點。