SMAILL JEFFREY BRUCE,PATTERSON ADAM VORN,LU GUO-LIANG,LEE HO HUAT,ASHOORZADEH AMIR,ANDERSON ROBERT FORBES,WILSON WILLIAM ROBERT,DENNY WILLIAM ALEXANDER,HSU HUAI-LING (ANNIE),MAROZ ANDREJ,JAMIESON STEP
申请号：
NZ59814410
公开号：
NZ598144A
申请日:
2010.09.02
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
598144 Disclosed herein are pyrido[3,4-d]pyrimidine compounds of formula (I) suitable as kinase inhibitors, kinase inhibitors in prodrug form, their use in compositions and medicaments which are suitable for the treatment of diseases related to kinase activity such as cancers. In one embodiment the compound is (2E)-4-({ 4-[3-chloro-4-(2-pyridinylmethoxy)anilino] pyrido[3,4-d]pyrimidin-6-yl} amino)-N,N-dimethyl-N-[(1-methyl-4-nitro-1H-imidazol-5-yl)methyl]-4-oxo-2-buten-1-ammonium bromide.
