The present invention: -A two-phase calcium phosphate/hydroxyapatite (CAP/HAP) bone substitute comprising a sintered CAP core and a closed epitaxial growth layer of nanocrystalline HAP deposited on the outer surface of the sintered CAP core, sintered CAP The closed epitaxy growth layer of nanocrystalline HAP deposited on the outer surface of the core has a homogeneous rough outer surface comprising flat crystalline platelets, Two-phase calcium phosphate/hydroxyapatite (CAP/HAP) bone substitutes with improved bone formation response, -It relates to a process for its preparation comprising the following steps: a) preparing a sintered CAP core material, b) starting the conversion process of CAP to HAP by immersing the sintered CAP core material in a buffer solution containing 90% of short-chain aliphatic alcohol at a temperature of 10°C to 0°C, nanocrystalline on the surface of the sintered CAP core material Forming a closed epitaxially grown layer of hydroxyapatite, the epitaxially grown nanocrystals have the same size and shape as a human bone mineral, and closed epitaxy of the nanocrystalline HAP formed on the surface of the sintered CAP core material. The grown layer has a homogeneous rough outer surface comprising flat crystalline platelets, c) separating the solid material from the aqueous solution at one time to stop the conversion when there is a closed coating of at least one nanocrystalline layer of HAP, but before the conversion process is completely finished, and d) optionally sterilizing the separated material resulting from step c).본 발명은:- 소결된 CAP 코어 및 소결된 CAP 코어의 외표면에 침착된 나노결정질 HAP 의 폐쇄된 에피택시 성장 층을 포함하는 2상 칼슘 포스페이트/히드록시아파타이트 (CAP/HAP) 골 대체 물질로서, 소결된 CAP 코어의 외표면에 침착된 나노결정질 HAP 의 폐쇄된 에피택시 성장 층은 편평한 결정 소판을 포함하는 균질한 거친 외표면을 갖고,향상된 골형성 반응을 보이는 2상 칼슘 포스페이트/히드록시아파타이트 (CAP/HAP) 골 대체 물질,- 하기 단계를 포함하는 이의 제조 방법에 관한 것이다:a) 소결된 CAP 코어 물질을 제조하는 단계,b) 10℃ 내지 0℃ 의 온도에서 90 % 의 단쇄 지방족 알코올을 함유하는 완충 용액에 소결된 CAP 코어 물질을 침지시켜 CAP 의 HAP 로의 변환 과정을 시작하여, 소결된 CAP 코어 물질 표
