An infusion cartridge for use with an ambulatory infusion system can be provided with a preattached infusion set to eliminate potential leakage, potential snagging and other inconveniences from tubing connectors. The infusion cartridge can include a rigid housing, a collapsible fluid reservoir within the housing and a dispense mechanism for drawing fluid from the reservoir and sending it out an outlet port. A length of tubing can be fixedly attached to the outlet port in fluid communication with the outlet port. The length of tubing can extend as a unitary construct from the outlet port to a connector that connects to a cannula for delivering fluid from the reservoir to a user.
