The invention provides human engineered antibodies, antigen-binding fragments thereof, that bind to, and inhibit the activity of, human DKK-1, and which are effective in treating diseases in which pathogenesis is mediated by DKK-1.本發明提供經改造(engineered)之人類抗體、其抗原結合片段,其結合人類DKK-1並抑制人類DKK-1活性,且可有效治療發病機制受DKK-1調介之疾病。