This description refers to uses, compositions, kits, Systems and Methods for treating overweight and obesity, through the use of Naltrexone Plus bupropion, preferably in combination with a comprehensive program of weight control managed by the Internet and by telephone and \/ or with P Reference in subjects who are at a higher risk of adverse Cardiovascular OutcomesLa presente descripcion se refiere a composiciones, kits, usos, sistemas y metodos para tratar el sobrepeso y la obesidad, mediante el uso de naltrexona mas bupropion, con preferencia, en combinacion con un programa integral de control de peso gestionado por internet y/o por via telefonica y, con preferencia, en sujetos que corren un de riesgo mayor de sufrir resultados cardiovasculares adversos
