KIHM, Anthony,HARRIS, Ian,MISTRY, Sanjay,HARMON, Alexander,MESSINA, Darin,SEYDA, Agnieszka,YI, Chin-Feng,GOSIEWSKA, Anna
申请号：
ES04777231
公开号：
ES2597837T3
申请日:
2004.06.25
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
An isolate of placental-derived cells obtainable from placental tissue after human delivery substantially free of blood, in which said cell self-renews and expands in culture, is multipotent, requires L-valine for growth, it grows in oxygen from about 5% to about 20%, and has the following additional characteristics: a) production of vimentin and alpha smooth muscle actin； b) expression of granulocyte-2 chemotactic protein (GCP-2) as detected by flow cytometry； c) lack of production of GRO-alpha and oxidized low density lipoprotein receptor, as detected by flow cytometry； d) production of CD10, CD13, CD44, CD73, CD90, PDGFr-alpha, PD-L2 and HLA-A, B, C, as detected by flow cytometry； e) lack of production of CD31, CD45, CD80, CD86, CD117, CD141, CD 178, B7-H2, HLA-G, and HLA-DP, DQ, DR, as detected by flow cytometry； f) expression, which is relative to a human cell that is a fibroblast, a mesenchymal stem cell, or an iliac crest bone marrow cell, is reduced for short stature homeobox 2； 27kDa heat shock protein 2； chemokine (C-X-C with motifs) ligand 12 (stromal factor 1 derived from cells)； elastin； DKFZp586M2022 cDNA (from clone DKFZp586M2022)； mesenchymal homeobox 2； homologue of homeobox sine oculis 1； crystalline, alpha B； disintegrated associated activator of morphogenesis 2； DKFZP586B2420 protein； similar to neuralin 1； tetranectin； src homologous three (SH3) and the cysteine-rich domain； B 1 cell translocation gene, anti-proliferative； cholesterol 25-hydroxylase； transcription factor related to runt-3； hypothetical protein FLJ23191； interleukin 11 receptor, alpha； procollagen promoter of C-endopeptidase； curly counterpart 7； hypothetical gene BC008967； collagen, type VIII, alpha 1； tenascin C； Iroquois 5 protein homeobox； hephaestin； integrin, beta 8； synaptic vesicle glycoprotein 2； CDNA FLJ12280 fis, Clone of MAMMA1001744； Factor-1 receptor cytokine as； intermediate potassium / small calcium conductance activated channel, subfamily N, member 4； integrin, a
