THE BRIGHAM AND WOMEN'S HOSPITAL,INC.;MASSACHUSETTS INSTITUTE OF TECHNOLOGY;NOVO NORDISK A/S
发明人:
ALEX G. ABRAMSON,BO ULDALL KRISTIANSEN,BRIAN JENSEN,CARLO GIOVANNI TRAVERSO,ESTER CAFFAREL SALVADOR,JORRIT JEROEN WATER,METTE POULSEN,MIKKEL OLIVER JESPERSEN,MINSOO KHANG,MORTEN REVSGAARD FREDERIKSEN
申请号：
BR112019023985
公开号：
BR112019023985A2
申请日:
2018.05.17
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
self-correcting articles, such as self-correcting capsules for administration to an individual, are generally provided. modalities include: a configuration so that the article can orient itself with respect to a surface (for example, a surface of the individual's tissue), one or more tissue fixation surfaces configured to wrap (for example, interact, inject in, anchor) with a surface (for example, a tissue surface of the individual) a particular shape and / or density (or mass) distribution that, for example, allows the self-correcting behavior of the article, a component of tissue interconnection and / or a pharmaceutical agent (for example, to release the active pharmaceutical agent to an internal location of the individual), configuration to release one or more components of tissue interconnection in contact of the tissue with the tissue fixation surface of the article, association. of the tissue interconnection component with a self-activating component. for example, the self-correcting article may comprise a self-adjusting component configured, upon exposure to a fluid, to release and the tissue interconnecting component of the self-correcting article. in some cases, the tissue interconnection component may comprise and / or be associated with the pharmaceutical agent (for example, for delivery to an internal location in an individual).artigos de autocorreção, tal como cápsulas de autocorreção para administração a um indivíduo, são geralmente fornecidos. modalidades incluem: uma configuração de modo que o artigo possa orientar-se com relação à uma superfície (por exemplo, uma superfície do tecido do indivíduo), uma ou mais superfícies de fixação tecidual configuradas para envolver-se (por exemplo, interagir, injetar em, ancorar) com uma superfície (por exemplo, uma superfície do tecido do indivíduo) uma forma particular e/ou distribuição de densidade (ou massa) que, por exemplo, permite o comportamento de autocorreção do artigo, um componente de interligação te
