PROBLEM TO BE SOLVED: To provide a novel surface modification substrate capable of being used preferably when fixing a bioactive substance to a substrate, especially, making a substrate surface carry an antigen, therefore capable of being used preferably in a wide range of applications such as immunity activation, and a production method of the same.SOLUTION: The production method of the surface modification substrate is configured to: radiate ultraviolet light to a mixture of a substrate (fibrous material), a substrate binding polymer containing a reaction unit and a cluster forming polymer unit 1, and a surface forming polymer containing a surface modification unit and a cluster forming polymer unit 2. An immunity activation material contains the surface modification group. A surface modification substrate in which the substrate binding polymer is a compound expressed by the formula (1).SELECTED DRAWING: Figure 3COPYRIGHT: (C)2017,JPO&INPIT【課題】生理活性物質等を基材に固定する際に好適に使用でき、特に基材表面に抗原を担持させることによって、免疫の賦活化等の幅広い用途に好適に使用できる新規な表面修飾基材及びその製造方法を提供する。【解決手段】基材(繊維質材料)、反応ユニット及び集合体形成ポリマーユニット1を有する基材結合ポリマー、並びに表面修飾ユニット及び集合体形成ポリマーユニット2を有する表面形成ポリマーの混合物に紫外線を照射することにより表面修飾基材を製造する方法。前記表面修飾基を含む免疫賦活化材料。基材結合ポリマーが式(1)で表される化合物である表面修飾基材。【選択図】図3
